As of November 13, 2026, 9 clinics in Columbia, SC see non-emergency pets same-day; 11 of the 11 listed clinics are open weekends. 2 are 24/7 emergency hospitals. 8 accept walk-ins.
Hours, walk-in rules and published exam fees come from each clinic's own site. Call before you drive.
Emergency signs? Go to a 24/7 ER now: trouble breathing, collapse, blue/gray gums, a long seizure, heavy bleeding, a toxin swallowed, or a male cat straining to pee. The 24/7 hospitals are at the bottom of the list. Full checklist: urgent care or ER? If you think your pet ate something poisonous, see the pet toxin checker.
Listings last checked: . That is the date this city's clinic data was checked against each clinic's own website.
"Open now" is computed in your browser from posted hours (America/New_York) and doesn't know about holidays. Clinics without itemized hours stay listed as "Hours unclear, call ahead." Call before you drive.
Urgent careSee hours
Truss Vet Veterinary Urgent Care - Columbia
4507 Forest Drive, Columbia, SC 29206
Closed Saturdays. On Saturday use CVETS Urgent Care, UrgentVet Lexington Square, or an ER.
Mon
10am–10pm
Tue
10am–10pm
Wed
10am–10pm
Thu
10am–10pm
Fri
10am–10pm
Sat
Closed
Sun
10am–10pm
Open 10am-10pm, closed Saturday. Sick and urgent visits only (no wellness or vaccines).
Walk-ins Yes
How to go No appointment needed; walk-ins welcome whenever open. You can also reserve a spot online.
How to go Walk-ins always welcome. Online booking (estimated times) is available Monday-Friday only; all patients are triaged on arrival. Call or text 803-995-8913.
116 Baker Griffing Dr, Suite A, Columbia, SC 29229
Closed Sundays. No urgent care hours on Mondays.
Mon
Closed
Tue
5pm–9pm
Wed
5pm–9pm
Thu
5pm–9pm
Fri
5pm–9pm
Sat
1pm–9pm
Sun
Closed
Walk-in urgent care hours: Tue-Fri 5pm-9pm, Sat 1pm-9pm. Regular clinic hours: Mon 9am-4pm, Tue-Fri 9am-9pm, Sat 1pm-9pm, Sun closed; during regular hours call and they will work you in if they can.
Walk-ins Yes
How to go No appointment needed during urgent care hours; call ahead to say you're coming. Most critical pets are seen first, then in order of arrival.
Closed the first weekend of every month, so hours are left unstructured. Call ahead.
HoursNot published
Walk-in urgent care: Thu-Fri 5pm-9:30pm, Sat 2pm-5:30pm, Sun 10am-1:30pm. Closed the 1st weekend of every month. Regular hours Mon-Thu 7:30am-8pm, Fri 7:30am-6pm, Sat 8am-12pm.
Walk-ins Yes
How to go Walk-ins welcome during urgent care hours; book regular visits online.
As of November 13, 2026, these listed clinics post Sunday hours: Truss Vet Veterinary Urgent Care - Columbia, CVETS Veterinary Urgent Care - West Columbia, UrgentVet - Lexington Square, Well Pets Veterinary Clinic and After Hours Urgent Care, Shandon-Wood Animal Clinic, Two Notch Road Animal Clinic, CVETS Northeast Columbia (Emergency & Specialty), and South Carolina Veterinary Specialists & Emergency Care (SCVSEC). Grace Animal (Urgent Care) says it is open weekends, but exact Sunday hours are not published; book online or call to confirm. WAG Vet (Urgent Care): Closed Sundays. No urgent care hours on Mondays. Other listed clinics are closed Sunday or have not published Sunday hours; see each card.
Is there a walk-in vet in Columbia?
Yes. As of November 13, 2026, these listed clinics say they accept walk-ins: Truss Vet Veterinary Urgent Care - Columbia, CVETS Veterinary Urgent Care - West Columbia, UrgentVet - Lexington Square, WAG Vet (Urgent Care), Grace Animal (Urgent Care), Two Notch Road Animal Clinic, CVETS Northeast Columbia (Emergency & Specialty), and South Carolina Veterinary Specialists & Emergency Care (SCVSEC). Call ahead, because a clinic may still be full. Clinics that have not published a walk-in policy are marked “not published” on their cards.
What's the difference between urgent care and an ER?
Urgent care and same-day clinics are for a sick pet that isn't in danger, such as vomiting, limping, small wounds, ear or eye problems, or a pet that's “off” but alert. A 24/7 emergency hospital is for trouble breathing, collapse, blue/gray gums, a long seizure, heavy bleeding, a toxin swallowed, or a male cat straining to pee. Many urgent-care clinics close overnight, and ERs see the sickest pets first, so minor cases may wait. On this page, CVETS Northeast Columbia (Emergency & Specialty) and South Carolina Veterinary Specialists & Emergency Care (SCVSEC) post 24/7 hours and are listed at the bottom. There is a full printable checklist at https://vetsopentoday.com/urgent-or-er.html.
Are there 24/7 emergency vets in Columbia?
Yes. As of November 13, 2026, CVETS Northeast Columbia (Emergency & Specialty) and South Carolina Veterinary Specialists & Emergency Care (SCVSEC) post 24/7 emergency hours.
